Professional
Technical
In the Industry Vocabulary Test
tumor heterogeneity
The genetic and phenotypic diversity within and between tumor samples from the same patient.
Full Definition
Tumor heterogeneity encompasses the complex genetic, epigenetic, and phenotypic variations that exist within individual tumors and between primary and metastatic sites in the same patient. This diversity poses significant challenges for precision oncology as it can lead to sampling bias in molecular profiling and contribute to therapeutic resistance. Understanding heterogeneity is crucial for interpreting molecular testing results and developing effective treatment strategies that account for tumor evolution.
Usage
Usage note: Can be used with intratumoral or intertumoral qualifiers for precision.
In Context
- "Significant tumor heterogeneity was observed between the primary site and liver metastases." — Molecular profiling report
- "The treatment plan accounted for potential tumor heterogeneity through combination therapy approaches." — Treatment strategy document
Also known as
intratumoral heterogeneity
tumor diversity
Contrasted with
clonal uniformity
genetic homogeneity
Don't confuse with
tumor evolution
clonal diversity