tumor profiling
Comprehensive molecular analysis of cancer tissue to identify actionable genetic alterations for treatment selection.
Full Definition
Tumor profiling encompasses the systematic analysis of cancer specimens using various molecular techniques to characterize genetic, epigenetic, and protein expression patterns. This includes DNA sequencing for mutations, RNA analysis for fusion genes and expression levels, and protein assessment through immunohistochemistry. The goal is to identify targetable molecular alterations that can guide precision therapy selection. Modern tumor profiling often employs panel-based sequencing covering hundreds of cancer-relevant genes, enabling simultaneous detection of multiple biomarkers. Results inform treatment decisions, clinical trial enrollment, and prognostic assessments.
Usage
Usage note: Distinguish from tumor staging or grading in clinical contexts
In Context
- "Comprehensive tumor profiling revealed an NTRK fusion suitable for targeted therapy." — Oncology consultation note
- "The tumor profiling report included mutation analysis, copy number variations, and PD-L1 expression." — Molecular diagnostics summary