Gestational choriocarcinoma
Pronunciation: kor-ee-oh-kar-sin-OH-mah
Malignant tumor arising from trophoblastic tissue that can occur after any pregnancy event.
Full Definition
Gestational choriocarcinoma is a highly aggressive malignant tumor that develops from trophoblastic tissue and can occur following any type of pregnancy, including normal pregnancies, molar pregnancies, miscarriages, or ectopic pregnancies. It is characterized by invasion of maternal tissues and early hematogenous spread, commonly to the lungs, brain, and liver. The tumor produces human chorionic gonadotropin (hCG), making serial hCG monitoring essential for diagnosis and treatment response. Despite its aggressive nature, choriocarcinoma is highly responsive to chemotherapy when detected early.
Usage
Usage note: Always specify gestational origin to distinguish from non-gestational choriocarcinoma.
In Context
- "Persistently elevated hCG levels six months postpartum raised suspicion for gestational choriocarcinoma." — Oncology consultation
- "Pulmonary metastases were identified in this case of gestational choriocarcinoma." — Staging documentation