CATIE study
Pronunciation: KAY-tee
Also written as: CATIE — Clinical Antipsychotic Trials of Intervention Effectiveness
Clinical Antipsychotic Trials of Intervention Effectiveness, a landmark pragmatic trial comparing antipsychotic medications.
Full Definition
The Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) was a large-scale, NIMH-funded pragmatic clinical trial conducted from 2001-2005 that compared the effectiveness of older and newer antipsychotic medications in treating schizophrenia. Unlike traditional efficacy trials, CATIE was designed to reflect real-world clinical practice and included patients typically excluded from pharmaceutical company trials. The study's findings significantly influenced psychiatric treatment guidelines and sparked debates about the relative benefits of first- and second-generation antipsychotics. CATIE's methodology and results are frequently referenced in psychiatric epidemiology literature as an example of effectiveness research.
Usage
Usage note: Always capitalize all letters; avoid referring to it as 'the CATIE trial' since 'trial' is redundant.
In Context
- "The CATIE study challenged assumptions about the superiority of atypical antipsychotics over conventional agents." — Literature review
- "Post-CATIE analyses have continued to yield insights into antipsychotic discontinuation patterns." — Research methodology