discontinuation syndrome
A cluster of symptoms occurring after abrupt cessation or significant dose reduction of psychiatric medications.
Full Definition
Discontinuation syndrome refers to a constellation of physical and psychological symptoms that can occur when psychiatric medications, particularly antidepressants and anxiolytics, are stopped abruptly or tapered too quickly. Symptoms may include dizziness, flu-like symptoms, sensory disturbances, anxiety, and mood changes. The syndrome is generally time-limited and can be minimized through gradual dose reduction. It differs from addiction withdrawal in that it occurs with therapeutic doses and does not indicate dependence or abuse potential.
Usage
Usage note: Distinguish from relapse or addiction withdrawal; occurs with therapeutic doses and proper medical use.
In Context
- "The study protocol included a structured taper schedule to minimize discontinuation syndrome risk." — Clinical trial protocol
- "Participants experiencing discontinuation syndrome were distinguished from those with disease relapse using standardized criteria." — Research methodology