responder analysis
Statistical analysis examining the proportion of patients achieving predefined improvement thresholds on clinical rating scales.
Full Definition
Responder analysis is a categorical approach to efficacy assessment that classifies patients as 'responders' or 'non-responders' based on achieving predetermined improvement criteria, typically expressed as percentage reduction from baseline on standardized rating scales. Common response thresholds include ≥50% reduction in HAMD-17 scores for depression or ≥30% reduction in PANSS total scores for schizophrenia. This analysis provides clinically meaningful interpretation of treatment effects and facilitates comparison across studies, though the choice of response threshold can significantly impact results and should be clinically justified.
Usage
Usage note: Distinguish from 'response analysis' which may refer to broader efficacy evaluation.
In Context
- "The responder analysis showed 65% of patients achieved ≥50% HAMD-17 improvement versus 35% on placebo." — Efficacy results
- "Secondary responder analyses included 30% and 75% improvement thresholds." — Statistical analysis plan