treatment-emergent mania
Manic or hypomanic episodes that develop during antidepressant treatment in individuals with bipolar disorder.
Full Definition
Treatment-emergent mania refers to the development of manic or hypomanic episodes during antidepressant therapy, typically occurring in individuals with undiagnosed bipolar disorder or those with known bipolar disorder receiving inadequate mood stabilization. This phenomenon represents a significant safety concern in psychiatric treatment and highlights the importance of careful diagnostic assessment before initiating antidepressants. The risk varies by antidepressant class and individual patient factors, with mood stabilizers often used as protective co-therapy in at-risk populations.
Usage
Usage note: Specify whether manic or hypomanic episodes; often requires treatment discontinuation or mood stabilizer addition.
In Context
- "The safety analysis identified three cases of treatment-emergent mania among participants receiving high-dose antidepressant monotherapy." — Safety report
- "Risk factors for treatment-emergent mania included family history of bipolar disorder and rapid cycling patterns." — Risk analysis