anticholinergic toxicity
Syndrome resulting from excessive blockade of acetylcholine receptors, characterized by 'hot as a hare, blind as a bat, dry as a bone, red as a beet, mad as a hatter.'
Full Definition
Anticholinergic toxicity is a potentially life-threatening condition caused by excessive blockade of muscarinic acetylcholine receptors. In psychopharmacology, it most commonly results from overdose or drug interactions involving tricyclic antidepressants, certain antipsychotics, or antiparkinsonian agents. Clinical presentation includes hyperthermia, mydriasis, dry mucous membranes, flushed skin, and delirium. Editors must recognize this term in toxicology reports and adverse event documentation, as it represents a medical emergency requiring immediate intervention.
Usage
Usage note: Note the distinction from general anticholinergic effects - toxicity implies severe, potentially dangerous symptoms.
In Context
- "The emergency department diagnosed anticholinergic toxicity following the patient's amitriptyline overdose." — toxicology report
- "Physostigmine was administered to reverse the anticholinergic toxicity." — treatment protocol