drug-induced mania
Manic episode triggered by medications, particularly antidepressants, stimulants, or corticosteroids, in susceptible individuals.
Full Definition
Drug-induced mania refers to the development of manic or hypomanic episodes as a direct consequence of medication exposure, most commonly occurring with antidepressants in individuals with underlying bipolar disorder or genetic vulnerability. The phenomenon is particularly associated with tricyclic antidepressants, selective serotonin reuptake inhibitors (SSRIs), and serotonin-norepinephrine reuptake inhibitors (SNRIs), though it can occur with any antidepressant class. Other medications implicated include stimulants, corticosteroids, levodopa, and certain antibiotics. The onset typically occurs within days to weeks of starting the medication or increasing the dose. Drug-induced mania often represents the first manifestation of bipolar disorder in previously undiagnosed individuals and can be severe, requiring immediate intervention. Management involves discontinuing the causative agent and initiating mood stabilizer therapy. Recognition of this phenomenon is crucial for preventing misdiagnosis and inappropriate continuation of triggering medications.
Usage
Usage note: Always specify the triggering medication and timing; distinguish from pre-existing mania exacerbated by medication.
In Context
- "The patient developed drug-induced mania three weeks after starting fluoxetine, suggesting underlying bipolar vulnerability." — Diagnostic assessment
- "Drug-induced mania represents a significant risk when prescribing antidepressants without mood stabilizer coverage." — Safety communication