drug tolerance
Decreased responsiveness to a drug following repeated administration, requiring higher doses for the same effect.
Full Definition
Drug tolerance is a pharmacological phenomenon characterized by the progressive diminution of response to a drug with repeated administration, necessitating increasingly larger doses to achieve the original therapeutic effect. Tolerance can develop through various mechanisms including receptor desensitization, enzyme induction, or compensatory physiological changes. In psychopharmacology, tolerance is particularly relevant for benzodiazepines, where patients may require dose escalation over time. Tolerance should be distinguished from physical dependence and addiction, though these phenomena may co-occur. Understanding tolerance patterns helps guide appropriate prescribing practices and dosing strategies.
Usage
Usage note: Distinguish from dependence and addiction in clinical documentation; specify type of tolerance when relevant.
In Context
- "The patient developed drug tolerance to lorazepam, requiring dose escalation to maintain anxiolytic effects." — Psychiatric consultation note
- "Strategies to minimize drug tolerance include intermittent dosing schedules and periodic drug holidays when clinically appropriate." — Treatment protocol