hyperprolactinemia
Pronunciation: HY-per-pro-LAK-tin-EE-mee-ah
Elevated serum prolactin levels, commonly caused by dopamine-blocking antipsychotic medications.
Full Definition
Hyperprolactinemia is an endocrine side effect characterized by abnormally high levels of prolactin hormone, frequently occurring with antipsychotic medications that block dopamine D2 receptors. Clinical manifestations include galactorrhea, amenorrhea, sexual dysfunction, and potential long-term consequences such as osteoporosis. This condition is particularly problematic with conventional antipsychotics and risperidone, but less common with prolactin-sparing agents like aripiprazole and quetiapine. Regular monitoring is essential in long-term antipsychotic treatment.
Usage
Usage note: Prefer 'hyperprolactinemia' over 'hyperprolactinaemia' in American medical writing.
In Context
- "Routine monitoring revealed hyperprolactinemia in 30% of patients receiving chronic risperidone treatment." — clinical study report
- "The patient's hyperprolactinemia resolved after switching from haloperidol to quetiapine." — case study