kindling
Neurobiological phenomenon where repeated subthreshold stimuli eventually trigger full seizures or mood episodes.
Full Definition
Kindling is a neuroplasticity mechanism originally described in epilepsy research, where repeated application of initially subthreshold electrical stimuli to brain tissue eventually produces spontaneous seizures. In psychopharmacology, the kindling hypothesis explains how recurrent mood episodes in bipolar disorder may become increasingly frequent and severe over time, potentially triggered by progressively smaller stressors. This concept underlies the rationale for maintenance mood stabilizer therapy and early intervention strategies in bipolar disorder treatment.
Usage
Usage note: Capitalize only when referring to the specific neurobiological model; lowercase when used descriptively.
In Context
- "The kindling hypothesis suggests that each untreated manic episode increases vulnerability to future episodes." — theoretical review
- "Lamotrigine's anti-kindling properties may contribute to its mood-stabilizing efficacy." — pharmacology textbook