prodrug
An inactive compound that is metabolized in the body to produce the active drug.
Full Definition
A prodrug is a pharmacologically inactive compound that undergoes biotransformation after administration to release the active drug. This approach is used to improve drug delivery, reduce side effects, or overcome formulation challenges. In psychopharmacology, prodrugs may be designed to cross the blood-brain barrier more effectively or to provide sustained release of the active compound. Examples include paliperidone palmitate, which is a prodrug of paliperidone used in long-acting injectable formulations for schizophrenia treatment.
Usage
Usage note: May be written as one word or hyphenated; ensure context makes clear the inactive nature of the administered compound.
In Context
- "The depot formulation uses a prodrug approach to provide sustained antipsychotic effects over several weeks." — Treatment plan
- "Converting the active compound to a prodrug improved its oral bioavailability and reduced gastrointestinal side effects." — Pharmaceutical development report