second-generation antipsychotic
Newer class of antipsychotic medications with reduced risk of extrapyramidal side effects compared to first-generation drugs.
Full Definition
Second-generation antipsychotics, also called atypical antipsychotics, are a class of psychiatric medications developed to treat psychotic disorders with fewer movement-related side effects than older antipsychotics. They typically have different receptor binding profiles, often targeting serotonin receptors in addition to dopamine receptors. Examples include risperidone, olanzapine, and quetiapine. While they have reduced extrapyramidal symptoms, they may carry increased risk of metabolic side effects such as weight gain and diabetes.
Usage
Usage note: Always hyphenate when used as an adjective; distinguish from first-generation antipsychotics in clinical documentation.
In Context
- "The patient was switched from haloperidol to a second-generation antipsychotic to reduce movement side effects." — Clinical assessment report
- "Second-generation antipsychotics require monitoring for metabolic parameters including weight and glucose levels." — Treatment protocol