Hypofractionation
Pronunciation: hi-po-frak-shuh-NAY-shun
A radiation therapy regimen using larger doses per fraction delivered over fewer treatment sessions than conventional fractionation.
Full Definition
Hypofractionation is a treatment approach in radiation oncology where higher doses per fraction are delivered in fewer sessions compared to conventional fractionation schedules. This technique exploits the radiobiological properties of certain tumors and normal tissues to improve therapeutic outcomes while reducing overall treatment time. Common in breast cancer and prostate cancer treatments, hypofractionation requires careful consideration of tissue tolerance and may utilize advanced delivery techniques to ensure safety.
Usage
Usage note: Not to be confused with hyperfractionation, which uses smaller doses delivered more frequently.
In Context
- "The oncologist recommended hypofractionation for the early-stage breast cancer patient to reduce treatment burden." — Treatment recommendation letter
- "Hypofractionation protocols require stringent quality assurance measures to ensure patient safety." — Clinical protocol document