fibrin sealant

Full Definition

Fibrin sealant is a topical hemostatic agent composed of fibrinogen and thrombin that polymerizes to form a fibrin clot, mimicking the final step of the coagulation cascade. In reconstructive surgery, fibrin sealants are commonly used to reduce seroma formation, secure tissue flaps, seal small vessels, and provide additional hemostasis in areas where traditional suturing may be difficult. The product may be autologous (prepared from the patient's own plasma) or commercially available preparations derived from human or bovine sources.

Usage

Usage note: Distinguish from synthetic adhesives and other hemostatic products in surgical documentation.

In Context

• "Fibrin sealant was applied to the donor site to minimize seroma formation." — operative report
• "The use of fibrin sealant reduced post-operative drainage volume compared to control cases." — clinical outcomes study