fragmentation rate
Percentage of cytoplasmic fragments in an embryo, used as a quality assessment parameter in IVF laboratories.
Full Definition
Fragmentation rate refers to the percentage of an embryo's volume that consists of anuclear cytoplasmic fragments, which are small cellular debris that lack genetic material. This parameter is commonly used to assess embryo quality during in vitro fertilization, as high fragmentation rates are associated with decreased implantation potential and pregnancy rates. Fragmentation is typically assessed on day 2 or day 3 of embryo development and is graded as none (0%), low (<10%), moderate (10-25%), or high (>25%). Embryos with minimal fragmentation are generally preferred for transfer, though the predictive value varies and should be considered alongside other morphological parameters.
Usage
Usage note: Express as percentage and specify day of assessment; correlate with other quality parameters.
In Context
- "The day 3 embryo showed a low fragmentation rate of 5% and was selected for transfer." — Laboratory report
- "Embryos with fragmentation rates exceeding 25% were not considered for fresh transfer." — Selection criteria