GnRH pump
Pulsatile delivery device for gonadotropin-releasing hormone used to restore normal reproductive function.
Full Definition
A GnRH pump is a programmable device that delivers gonadotropin-releasing hormone in a pulsatile manner, mimicking the natural hypothalamic secretion pattern. This treatment is primarily used for patients with hypothalamic amenorrhea or Kallmann syndrome who have deficient or absent GnRH production. The pump delivers precise doses of GnRH subcutaneously every 90-120 minutes, stimulating the pituitary to produce LH and FSH in physiological patterns. This approach can restore ovulation in women and spermatogenesis in men with hypothalamic hypogonadism, offering an alternative to direct gonadotropin therapy.
Usage
Usage note: Specify dosing frequency and distinguish from continuous GnRH administration methods.
In Context
- "The GnRH pump was programmed to deliver 5 micrograms every 90 minutes." — Treatment protocol
- "GnRH pump therapy restored regular ovulation in the patient with hypothalamic amenorrhea." — Treatment outcome report