luteal phase defect
Pronunciation: LOO-tee-ul fayze DEE-fekt
Inadequate progesterone production after ovulation causing implantation failure. A treatable cause of recurrent pregnancy loss.
Full Definition
Luteal phase defect (LPD) refers to inadequate progesterone production by the corpus luteum following ovulation, resulting in insufficient preparation of the endometrium for implantation. This condition can manifest as either a shortened luteal phase (less than 10 days) or inadequate progesterone levels despite normal luteal phase length. LPD can lead to implantation failure, early pregnancy loss, or irregular menstrual cycles. Diagnosis may involve serial progesterone measurements, endometrial biopsy, or luteal phase length assessment. Treatment typically includes progesterone supplementation, which can be administered via various routes including vaginal suppositories, oral tablets, or intramuscular injections. LPD is considered a potentially correctable cause of infertility and recurrent pregnancy loss.
Usage
Usage note: Often abbreviated as LPD; ensure consistency in terminology as some sources use 'insufficiency' rather than 'defect'.
In Context
- "Luteal phase defect was suspected based on consistently low mid-luteal progesterone levels." — Diagnostic evaluation report
- "Treatment of luteal phase defect with progesterone supplementation resulted in successful conception." — Treatment outcome documentation