ovarian hyperstimulation syndrome
Also written as: OHSS — Ovarian Hyperstimulation Syndrome
Potentially serious complication of fertility treatment causing ovarian enlargement and fluid accumulation.
Full Definition
Ovarian hyperstimulation syndrome (OHSS) is an iatrogenic complication of controlled ovarian hyperstimulation that can range from mild to life-threatening severity. The condition is characterized by ovarian enlargement, increased vascular permeability, and fluid shifts leading to ascites, pleural effusion, and hemoconcentration. OHSS typically occurs after administration of human chorionic gonadotropin (hCG) trigger or during early pregnancy when endogenous hCG levels rise. Risk factors include young age, polycystic ovary syndrome, and high ovarian response to stimulation. Prevention strategies include careful monitoring during stimulation, GnRH agonist triggers, and embryo cryopreservation to avoid fresh transfers in high-risk patients.
Usage
Usage note: Always distinguish from the intended controlled ovarian hyperstimulation procedure.
In Context
- "The patient developed mild ovarian hyperstimulation syndrome with abdominal distension and discomfort." — Medical record
- "Prevention of ovarian hyperstimulation syndrome requires careful risk assessment and protocol modification." — Clinical guideline