blastocyst biopsy
Procedure to remove cells from the outer layer of a 5-6 day embryo for genetic testing. Distinguished from earlier-stage trophectoderm sampling.
Full Definition
A laboratory technique used in preimplantation genetic diagnosis where a small number of cells are removed from the outer cell layer (trophectoderm) of a blastocyst-stage embryo, typically on day 5 or 6 of development. This biopsy allows genetic testing without significantly compromising the embryo's developmental potential. The procedure requires precise timing and technique, as the embryo must be sufficiently developed to yield adequate genetic material while maintaining viability for transfer. Blastocyst biopsy has largely replaced earlier methods due to improved accuracy and reduced risk of embryonic damage.
Usage
Usage note: Always specify the developmental stage when discussing embryonic biopsy procedures.
In Context
- "The laboratory protocol specified blastocyst biopsy on day 6 to ensure adequate cell yield for chromosomal analysis." — Laboratory procedure manual
- "Patient consent forms must clearly distinguish between blastocyst biopsy and earlier embryonic sampling methods." — Informed consent documentation