multifactorial inheritance
A pattern of inheritance involving multiple genes combined with environmental factors that together contribute to a trait or condition.
Full Definition
Multifactorial inheritance, also called complex or polygenic inheritance, describes conditions that result from the interaction of multiple genetic variants along with environmental influences. Unlike single-gene disorders, multifactorial conditions do not follow simple Mendelian inheritance patterns and typically show familial clustering without clear dominant or recessive patterns. Examples include neural tube defects, congenital heart defects, and cleft lip/palate, which are important considerations in reproductive genetics counseling.
Usage
Usage note: May also be described as 'complex genetic inheritance' in patient materials.
In Context
- "The recurrence risk for multifactorial inheritance is typically 2-5% for first-degree relatives." — Genetic counseling guideline
- "Neural tube defects demonstrate multifactorial inheritance with both genetic susceptibility and folate deficiency contributing to risk." — Research publication