pedigree analysis
Systematic evaluation of family medical history using standardized symbols to trace inheritance patterns of genetic conditions across generations.
Full Definition
Pedigree analysis is a fundamental tool in reproductive genetics that involves creating and interpreting family trees using standardized symbols to represent individuals, relationships, and genetic conditions. The analysis helps identify inheritance patterns (autosomal dominant, autosomal recessive, X-linked, or multifactorial), calculate recurrence risks, and guide appropriate genetic testing strategies. Accurate pedigree construction requires detailed family history collection spanning at least three generations and is essential for genetic counseling, risk assessment, and reproductive planning.
Usage
Usage note: Always hyphenate as compound term; 'pedigree' alone refers to the diagram itself.
In Context
- "Pedigree analysis revealed an autosomal dominant inheritance pattern for the familial cancer syndrome." — Genetic counseling notes
- "The three-generation pedigree analysis helped identify the proband's risk for Huntington disease." — Clinical genetics consultation