Agonist Protocol
Pronunciation: AG-oh-nist PROH-toh-kol
An IVF stimulation regimen using GnRH agonist for pituitary suppression before ovarian stimulation.
Full Definition
The agonist protocol is a controlled ovarian stimulation approach that uses GnRH agonist to suppress natural hormone production before introducing exogenous gonadotrophins. The protocol typically involves either a long protocol (starting in the prior cycle's luteal phase) or short protocol (starting with stimulation). Initial agonist administration causes an LH/FSH flare, followed by receptor downregulation and pituitary suppression. This prevents premature ovulation and allows controlled follicular recruitment. The protocol may take longer than antagonist protocols but offers excellent cycle control and has extensive safety data.
Usage
Usage note: Often contrasted with antagonist protocols in treatment planning discussions.
In Context
- "The agonist protocol was selected for this patient due to her history of premature ovulation." — Protocol selection rationale
- "Downregulation was confirmed before starting gonadotrophin stimulation in the agonist protocol." — Monitoring documentation