Clomiphene Citrate
Pronunciation: KLOH-mih-feen SIT-rate
Oral ovulation induction medication that blocks estrogen receptors to stimulate follicle development. Brand names include Clomid and Serophene.
Full Definition
A selective estrogen receptor modulator (SERM) used as first-line treatment for ovulation induction in women with anovulatory infertility, particularly those with polycystic ovary syndrome. Clomiphene citrate works by blocking estrogen receptors in the hypothalamus, leading to increased FSH and LH secretion, which stimulates ovarian follicle development. Treatment typically begins with 50mg daily for 5 days, starting on cycle day 3-5. Monitoring includes follicular tracking and may include ovulation predictor kits or serum progesterone levels. Success rates are highest in the first three treatment cycles.
Usage
Usage note: Brand names Clomid and Serophene are often used interchangeably in clinical documentation.
In Context
- "The patient was started on clomiphene citrate 50mg for ovulation induction after confirming anovulation." — Treatment protocol
- "Clomid monitoring revealed three mature follicles, requiring cycle cancellation due to high-order multiple risk." — Cycle report