Professional
Technical
IVT
gonadotrophin-releasing hormone agonist
A synthetic hormone that initially stimulates then suppresses natural hormone production in fertility treatments.
Full Definition
A synthetic analogue of the naturally occurring gonadotrophin-releasing hormone that is used in assisted reproductive technology protocols. Initially, GnRH agonists stimulate the release of FSH and LH, but with continued use they cause downregulation and suppression of the pituitary gland. This allows clinicians to control the timing of ovulation and prevent premature luteinizing hormone surges during IVF cycles.
Usage
Usage note: Editors should distinguish between agonists (which eventually suppress) and antagonists (which immediately block).
In Context
- "The patient will begin gonadotrophin-releasing hormone agonist injections on day 21 of her cycle." — Treatment protocol
- "Long-acting GnRH agonists require careful monitoring to avoid over-suppression." — Clinical guidelines
Also known as
GnRH agonist
gonadotropin-releasing hormone analogue
Contrasted with
GnRH antagonist
Don't confuse with
GnRH antagonist
gonadotrophin