lymphovascular invasion
Also written as: LVI — Lymphovascular Invasion
Presence of tumor cells within lymphatic vessels or blood vessels, indicating aggressive tumor behavior and metastatic potential.
Full Definition
Lymphovascular invasion (LVI) refers to the identification of tumor cells within the lumina of lymphatic or blood vessels on histopathological examination. This finding represents an important prognostic factor across many cancer types, as it indicates the tumor's ability to invade vessels and potentially metastasize to distant sites. LVI presence often upstages tumors, influences adjuvant treatment decisions, and is associated with higher recurrence rates and poorer overall survival. Pathologists specifically examine tissue sections for evidence of LVI as part of routine cancer staging.
Usage
Usage note: Commonly abbreviated as LVI in pathology reports.
In Context
- "Histopathological examination revealed extensive lymphovascular invasion throughout the specimen." — pathology report
- "The presence of lymphovascular invasion upgraded the tumor stage and influenced the adjuvant treatment recommendation." — multidisciplinary team discussion