oligoprogression
Limited disease progression in few metastatic sites while other disease remains controlled.
Full Definition
Oligoprogression refers to a clinical scenario where cancer progresses in a limited number of metastatic sites (typically 1-5 lesions) while the majority of disease remains stable or controlled by systemic therapy. This pattern of progression suggests that subclones of cancer cells in specific locations have developed resistance to treatment while other sites remain sensitive. Oligoprogression presents an opportunity for local ablative therapies such as stereotactic radiation, radiofrequency ablation, or surgical resection of progressing lesions while continuing effective systemic therapy. This approach may extend the duration of systemic treatment effectiveness and delay the need for treatment changes.
Usage
Usage note: Specify the number and location of progressing sites and the status of other disease sites.
In Context
- "Imaging demonstrated oligoprogression in two liver lesions while lung metastases remained stable." — Oncology follow-up note
- "The patient was referred for ablation of oligoprogression sites to continue current systemic therapy." — Treatment planning conference