positive margins
Presence of cancer cells at the edge of surgically removed tissue, indicating incomplete tumor removal.
Full Definition
Positive margins refer to the histopathological finding of malignant cells present at or within 1-2 millimeters of the resection edge of a surgical specimen. This finding indicates that the tumor extends to the boundary of the excised tissue, suggesting that cancer cells may remain in the patient. Positive margins are associated with increased risk of local recurrence and may necessitate additional treatment such as re-excision, radiation therapy, or systemic therapy. The significance of positive margins varies by cancer type, location, and clinical context. Margin status is a critical quality indicator in cancer surgery and influences staging, prognosis, and subsequent treatment planning. Careful intraoperative assessment and communication between surgeon and pathologist are essential for optimal margin evaluation.
Usage
Usage note: Use plural 'margins' even when referring to single surgical specimen. Hyphenate when used as compound modifier.
In Context
- "Pathology revealed positive margins requiring additional wide local excision." — Pathology report
- "The patient was counseled about positive margins and options for further treatment." — Clinical note