lepidic growth pattern
Pronunciation: leh-PID-ik
A histological pattern where tumor cells grow along alveolar septa without destroying lung architecture.
Full Definition
The lepidic growth pattern is characterized by neoplastic cells spreading along the surface of alveolar septa in a non-invasive manner, preserving the underlying lung architecture. This growth pattern is the defining feature of adenocarcinoma in situ and is a component of minimally invasive adenocarcinoma. When lepidic growth predominates in invasive adenocarcinomas, it defines the lepidic-predominant subtype, which generally has a more favorable prognosis. Recognition of lepidic patterns is crucial for accurate histological classification and staging, as purely lepidic growth (without invasion) indicates earlier-stage disease with excellent prognosis when completely resected.
Usage
Usage note: Derived from Greek 'lepis' meaning scale; ensure correct spelling and usage context.
In Context
- "The tumor showed predominantly lepidic growth pattern with focal micropapillary invasion." — Pathology report
- "Lepidic-predominant adenocarcinomas typically present as ground-glass opacities on imaging." — Research article