targeted therapy
Precision cancer treatment directed at specific molecular targets or genetic mutations in tumor cells.
Full Definition
Targeted therapy in thoracic oncology refers to treatments that specifically target molecular abnormalities or genetic mutations present in cancer cells, offering a more precise approach than traditional chemotherapy. Common targets in lung cancer include EGFR mutations, ALK rearrangements, ROS1 fusions, BRAF mutations, and others. These therapies typically involve small molecule inhibitors or monoclonal antibodies that block specific pathways essential for cancer cell growth and survival. Targeted therapy often provides better efficacy and tolerability compared to chemotherapy in patients whose tumors harbor the corresponding molecular targets, but resistance typically develops over time, requiring sequential treatment strategies.
Usage
Usage note: Specify the target when known (EGFR-targeted, ALK-targeted); distinguish from immunotherapy.
In Context
- "The patient achieved excellent response to targeted therapy with osimertinib for EGFR-mutated lung cancer." — Treatment response note
- "Comprehensive genomic profiling is essential for identifying candidates for targeted therapy." — Molecular testing protocol