vascular remodeling
Adaptive changes in blood vessel structure and geometry in response to altered hemodynamic conditions or pathological processes.
Full Definition
Vascular remodeling encompasses the structural adaptations that blood vessels undergo in response to various stimuli, including changes in flow, pressure, or pathological conditions such as atherosclerosis. This process involves alterations in vessel diameter, wall thickness, and cellular composition through mechanisms of cell growth, death, migration, and extracellular matrix modification. Positive remodeling results in vessel enlargement to maintain luminal area despite plaque development, while negative remodeling leads to vessel shrinkage and luminal compromise. Constrictive remodeling may occur following angioplasty or stent placement. Understanding remodeling patterns is crucial for interpreting vascular imaging and predicting treatment outcomes. Editors must distinguish between different types of remodeling and ensure consistent terminology when describing these adaptive processes.
Usage
Usage note: Specify the type of remodeling (positive, negative, constrictive) and provide context for the underlying stimulus when possible.
In Context
- "Positive vascular remodeling preserved luminal dimensions despite significant plaque accumulation." — Interventional cardiology research
- "Constrictive vascular remodeling contributed to late lumen loss following balloon angioplasty." — Interventional procedure follow-up