Professional
Technical
IVT
ISR
Also written as: ISR — in-stent restenosis
In-stent restenosis; re-narrowing of vessel lumen within a previously implanted stent.
Full Definition
In-stent restenosis (ISR) refers to the re-narrowing of a vessel lumen within a previously implanted stent, typically defined as greater than 50% diameter stenosis by angiography. ISR results from neointimal hyperplasia, a healing response involving smooth muscle cell proliferation and extracellular matrix deposition within the stent. Treatment options include balloon angioplasty, drug-eluting balloon therapy, repeat stenting, or in severe cases, surgical revascularization.
Usage
Usage note: Distinguish from stent thrombosis, which is acute vessel closure, not gradual re-narrowing.
In Context
- "Angiography revealed significant ISR requiring repeat intervention of the previously treated vessel." — Diagnostic report
- "The patient presented with recurrent angina secondary to ISR in the left anterior descending artery." — Clinical presentation
Also known as
in-stent restenosis
Contrasted with
stent patency
Don't confuse with
stent thrombosis
restenosis