hyperviscosity syndrome
Clinical condition caused by increased blood viscosity leading to impaired circulation and organ dysfunction.
Full Definition
Hyperviscosity syndrome occurs when blood viscosity increases sufficiently to impair circulation, typically due to elevated protein levels (paraproteins) or increased cellular components. Common causes include multiple myeloma, Waldenström's macroglobulinemia, and polycythemia vera. Clinical manifestations include neurological symptoms (confusion, headache), visual disturbances, bleeding tendencies, and cardiovascular compromise. The syndrome is diagnosed based on clinical presentation and viscosity measurements, with treatment focused on the underlying cause and plasma exchange when indicated.
Usage
Usage note: Ensure distinction from simple polycythemia; syndrome requires clinical manifestations.
In Context
- "The patient's visual symptoms and elevated serum viscosity confirmed hyperviscosity syndrome." — Hematology consultation
- "Plasmapheresis rapidly improved the patient's neurological status in hyperviscosity syndrome." — Treatment response note