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no-reflow phenomenon
Impaired tissue perfusion despite successful restoration of epicardial vessel patency following intervention.
Full Definition
The no-reflow phenomenon describes inadequate myocardial or tissue perfusion that persists after successful mechanical restoration of vessel patency during interventional procedures. This occurs due to microvascular dysfunction caused by distal embolization, vasospasm, or inflammatory responses. In vascular medicine, it can complicate thrombolysis or mechanical thrombectomy procedures, resulting in poor clinical outcomes despite angiographically successful recanalization.
Usage
Usage note: Distinguish from technical procedural failure; vessel is patent but perfusion remains impaired.
In Context
- "Despite successful clot removal, the patient demonstrated no-reflow phenomenon with poor distal perfusion." — Procedural report
- "Pharmacologic agents were administered to address the no-reflow phenomenon observed during the intervention." — Treatment documentation
Also known as
slow-flow phenomenon
microvascular obstruction
Contrasted with
normal perfusion
Don't confuse with
vasospasm
distal embolization