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Technical
IVT
ischemia-reperfusion injury
Tissue damage that occurs when blood supply returns to tissue after prolonged ischemia.
Full Definition
Ischemia-reperfusion injury is a complex pathophysiological process where tissue damage occurs not only during the period of reduced blood flow (ischemia) but also paradoxically increases when circulation is restored (reperfusion). This phenomenon is particularly relevant in vascular surgery when revascularizing chronically ischemic tissues. The injury results from oxidative stress, inflammatory cascade activation, and cellular dysfunction that can lead to compartment syndrome, organ dysfunction, and systemic complications following successful revascularization procedures.
Usage
Usage note: Hyphenated when used as a compound noun.
In Context
- "The patient developed severe ischemia-reperfusion injury following successful thrombectomy of the femoral artery." — clinical progress note
- "Prophylactic fasciotomy was performed to mitigate the risk of ischemia-reperfusion injury." — operative report
Also known as
reperfusion injury
post-ischemic injury
Don't confuse with
compartment syndrome
acute limb ischemia