Professional
Technical
IVT
physiologic derangement
Abnormal physiological state characterized by acidosis, hypothermia, and coagulopathy in trauma patients.
Full Definition
A pathophysiologic condition commonly seen in severely injured patients where normal homeostatic mechanisms fail, resulting in metabolic acidosis, hypothermia, and bleeding disorders. This triad of derangements often dictates surgical decision-making in acute care surgery, particularly the timing of damage control interventions versus definitive repair. Recognition of physiologic derangement guides patient triage and operative planning.
Usage
Usage note: Avoid redundancy with 'physiologic exhaustion' - they refer to the same concept.
In Context
- "Significant physiologic derangement precluded immediate definitive reconstruction." — Operative report
- "The patient exhibited signs of physiologic derangement including hypothermia and acidosis." — Clinical assessment
Also known as
physiologic exhaustion
metabolic failure
Contrasted with
physiologic reserve
hemodynamic stability
Don't confuse with
physiologic reserve
hemodynamic instability