vasospastic angina
Chest pain caused by coronary artery spasm rather than fixed atherosclerotic obstruction.
Full Definition
Vasospastic angina, also known as Prinzmetal's angina or variant angina, is a form of coronary artery disease characterized by transient coronary artery spasm causing myocardial ischemia in the absence of significant fixed coronary stenosis. Episodes typically occur at rest, often during nighttime or early morning hours, and may be triggered by stress, cold exposure, or certain medications. Diagnosis is confirmed by demonstrating coronary spasm during angiography, often with provocative testing using acetylcholine or ergonovine. Treatment focuses on calcium channel blockers and nitrates, while beta-blockers may paradoxically worsen symptoms.
Usage
Usage note: Also known as Prinzmetal's angina; calcium channel blockers are first-line therapy.
In Context
- "The patient's nocturnal chest pain and transient ST elevation suggested vasospastic angina." — Emergency department evaluation
- "Provocative testing with acetylcholine confirmed the diagnosis of vasospastic angina." — Cardiac catheterization report