tau protein
Pronunciation: tow protein
Microtubule-associated protein that forms pathological aggregates in Alzheimer's disease and other tauopathies.
Full Definition
Tau is a microtubule-associated protein normally involved in maintaining neuronal cytoskeletal structure and axonal transport. In neurodegenerative diseases, tau becomes hyperphosphorylated and aggregates into paired helical filaments, forming neurofibrillary tangles characteristic of Alzheimer's disease. Tau pathology also defines other conditions collectively termed 'tauopathies,' including frontotemporal dementia, progressive supranuclear palsy, and corticobasal degeneration. The pattern and distribution of tau deposits help distinguish between these disorders and correlate with clinical symptoms better than amyloid plaques.
Usage
Usage note: Distinguish from other proteinopathies; specify whether discussing normal or pathological tau when relevant.
In Context
- "Tau PET imaging revealed significant tracer uptake in the temporal and parietal cortices." — Molecular imaging report
- "CSF tau levels were markedly elevated, supporting the diagnosis of Alzheimer's disease." — Biomarker analysis report