treatment-resistant depression
Depression that has not responded adequately to at least two trials of antidepressant medications.
Full Definition
Treatment-resistant depression (TRD) is a clinical condition where a patient's major depressive disorder has not responded adequately to at least two trials of antidepressant medications from different pharmacological classes, given at adequate doses for sufficient duration. This condition affects approximately 30% of patients with depression and may require alternative treatment approaches such as augmentation strategies, combination therapies, psychotherapy, or interventional procedures like electroconvulsive therapy or transcranial magnetic stimulation.
Usage
Usage note: Ensure clear criteria are met before using this term; often abbreviated as TRD in clinical notes.
In Context
- "The patient met criteria for treatment-resistant depression after failing trials of sertraline and venlafaxine." — Clinical assessment
- "Alternative treatments for treatment-resistant depression include ketamine and ECT." — Treatment guidelines