critical limb ischemia
Also written as: CLI — critical limb ischemia
Advanced stage of peripheral arterial disease characterized by chronic ischemic rest pain or tissue loss threatening limb viability.
Full Definition
Critical limb ischemia (CLI) represents the most severe manifestation of peripheral arterial disease, characterized by chronic ischemic rest pain, non-healing wounds, or gangrene due to inadequate blood flow. Patients typically experience pain at rest, particularly at night, and may develop ulceration or tissue necrosis. CLI carries a high risk of limb loss and mortality if untreated. Diagnosis is confirmed by specific hemodynamic criteria including ankle pressure less than 50 mmHg or toe pressure less than 30 mmHg, combined with clinical signs of severe ischemia.
Usage
Usage note: Recently updated terminology prefers 'chronic limb-threatening ischemia' (CLTI) in some guidelines.
In Context
- "The patient presented with critical limb ischemia manifesting as rest pain and a non-healing toe ulcer." — Emergency department note
- "Urgent revascularization was indicated given the diagnosis of critical limb ischemia." — Vascular surgery consultation