quinidine syncope
Pronunciation: KWIN-ih-deen SIN-ko-pee
Sudden loss of consciousness caused by quinidine-induced torsades de pointes. A rare but potentially fatal complication of quinidine therapy.
Full Definition
Quinidine syncope is a sudden loss of consciousness resulting from quinidine-induced torsades de pointes, a polymorphic ventricular tachycardia. This adverse effect is related to quinidine's class IA antiarrhythmic properties, which can prolong the QT interval and create conditions favorable for this dangerous arrhythmia. The syndrome was historically significant in early antiarrhythmic therapy and led to increased awareness of drug-induced arrhythmias. Modern clinical practice requires careful QT monitoring when quinidine is used, though the drug is now rarely prescribed due to safer alternatives.
Usage
Usage note: Capitalize 'Quinidine' when referring to the drug name; lowercase 'quinidine' when used as an adjective.
In Context
- "The patient experienced quinidine syncope three days after initiating therapy for atrial fibrillation." — Cardiology consultation note
- "Quinidine syncope remains a classic example of proarrhythmic drug effects in antiarrhythmic therapy." — Medical literature review