fractional flow reserve
Also written as: FFR — fractional flow reserve
Invasive hemodynamic measurement comparing maximum blood flow distal to a stenosis with theoretical maximum flow in a normal vessel.
Full Definition
Fractional flow reserve (FFR) is a sophisticated invasive diagnostic technique that quantifies the functional significance of coronary or peripheral arterial stenoses by measuring pressure gradients across lesions during maximal hyperemia. The measurement involves advancing a pressure-sensitive guidewire distal to the suspected stenosis and inducing pharmacological vasodilation to achieve maximum flow conditions. FFR values range from 0 to 1.0, with values ≤0.80 indicating hemodynamically significant stenosis requiring intervention. This technique helps distinguish between anatomically apparent but functionally insignificant lesions and those requiring revascularization, thereby improving clinical decision-making and reducing unnecessary procedures.
Usage
Usage note: Commonly abbreviated as FFR; ensure distinction from anatomical assessment methods.
In Context
- "Fractional flow reserve measurement of 0.75 confirmed the hemodynamic significance of the mid-LAD stenosis." — Cardiac catheterization report
- "Despite angiographic appearance of moderate stenosis, fractional flow reserve of 0.85 indicated no functional impairment." — Interventional decision-making