Gonadotropin-Releasing Hormone Agonist
Also written as: GnRH agonist — Gonadotropin-Releasing Hormone Agonist
Medication used to suppress natural hormone production during fertility treatments.
Full Definition
Gonadotropin-releasing hormone agonists are synthetic hormones that initially stimulate and then suppress the pituitary gland's production of luteinizing hormone and follicle-stimulating hormone. In ART protocols, GnRH agonists are used to prevent premature luteinizing hormone surges during controlled ovarian stimulation, allowing for better control of the treatment cycle. Common GnRH agonists include leuprolide, goserelin, and nafarelin, which can be administered through various routes including subcutaneous injection, nasal spray, or depot formulations.
Usage
Usage note: Distinguish carefully from GnRH antagonists, which have opposite timing in protocols.
In Context
- "The patient received daily GnRH agonist injections to suppress her natural cycle." — medication protocol
- "Long protocol with GnRH agonist downregulation was chosen for this high responder." — treatment plan