Granulosa Cells
Follicular cells that support oocyte development and produce hormones during folliculogenesis and ovarian stimulation.
Full Definition
Granulosa cells are somatic cells that surround and nourish the developing oocyte within ovarian follicles. They form the inner layer of the follicle and are responsible for producing estradiol, progesterone, and other factors essential for oocyte maturation. During controlled ovarian stimulation, granulosa cells respond to FSH and LH, proliferating and producing increasing amounts of estradiol. At oocyte retrieval, granulosa cells are aspirated along with the oocyte and follicular fluid. Their presence and appearance can provide information about oocyte quality and follicular development.
Usage
Usage note: Important for understanding follicular physiology and oocyte quality assessment.
In Context
- "Granulosa cell expansion was observed in mature follicles during the final stages of stimulation." — Ovarian monitoring report
- "The presence of luteinized granulosa cells in follicular aspirate indicated adequate hCG response." — Laboratory embryology note