aromatase inhibitor
Pronunciation: uh-ROH-muh-tayss in-HIB-i-ter
A class of hormone therapy drugs that block estrogen production in postmenopausal women with hormone receptor-positive breast cancer.
Full Definition
Aromatase inhibitors (AIs) are medications that block the enzyme aromatase, which converts androgens to estrogens in postmenopausal women. By reducing estrogen levels, these drugs help prevent hormone receptor-positive breast cancer cells from receiving growth signals. Common aromatase inhibitors include anastrozole, letrozole, and exemestane. They are typically used as adjuvant therapy in postmenopausal women or in metastatic settings. Side effects may include bone loss, joint pain, and menopausal symptoms. AIs are generally more effective than tamoxifen in postmenopausal women.
Usage
Usage note: Specify generic name (anastrozole, letrozole, exemestane) when discussing specific agents.
In Context
- "The patient was switched from tamoxifen to an aromatase inhibitor after becoming postmenopausal." — Treatment modification note
- "Aromatase inhibitor therapy will continue for five years with annual bone density monitoring." — Follow-up care plan