atypical ductal hyperplasia

Full Definition

Atypical ductal hyperplasia (ADH) is a proliferative breast lesion involving abnormal epithelial cell growth within the ductal system. While not malignant, ADH is considered a high-risk marker that increases a woman's lifetime breast cancer risk by approximately 4-5 fold. On histological examination, ADH shares some features with ductal carcinoma in situ but lacks the full criteria for malignancy. Clinical management typically involves increased surveillance with enhanced screening protocols.

Usage

Usage note: Often abbreviated as ADH in clinical documentation.

In Context

• "The core biopsy revealed atypical ductal hyperplasia, prompting referral to high-risk clinic for enhanced surveillance." — Pathology report
• "Patients with atypical ductal hyperplasia should be counseled regarding their elevated breast cancer risk." — Clinical consultation note