lobular carcinoma in situ
A proliferative breast lesion characterized by abnormal cell growth within breast lobules, considered a high-risk marker rather than true cancer.
Full Definition
Lobular carcinoma in situ (LCIS) is a benign proliferative condition where abnormal cells fill and distend the terminal duct lobular units of the breast. Despite its name containing 'carcinoma,' LCIS is not considered cancer but rather a high-risk lesion that indicates increased susceptibility to developing invasive breast cancer in either breast. Women with LCIS have approximately a 7-fold increased risk of developing invasive breast cancer compared to the general population. The lesion is typically discovered incidentally during breast biopsy performed for other reasons, as it does not form palpable masses or appear on imaging studies. Management strategies include increased surveillance, risk-reducing medications, or prophylactic surgery in select cases.
Usage
Usage note: Often abbreviated as LCIS in clinical documentation; emphasize that it is not invasive cancer when communicating with patients.
In Context
- "The biopsy revealed lobular carcinoma in situ, prompting discussion of enhanced surveillance options." — Clinical consultation note
- "Lobular carcinoma in situ was an incidental finding on the core needle biopsy." — Pathology report