metaplastic breast carcinoma
A rare subtype of invasive breast cancer characterized by malignant cells that have undergone metaplastic transformation to non-glandular elements.
Full Definition
Metaplastic breast carcinoma is an uncommon and aggressive form of invasive breast cancer, accounting for less than 1% of all breast malignancies. The tumor is characterized by the presence of malignant epithelial cells that have transformed into non-glandular elements such as squamous cells, spindle cells, or mesenchymal components like cartilage or bone. This subtype is typically triple-negative, meaning it lacks expression of estrogen receptors, progesterone receptors, and HER2. Due to its rarity and aggressive nature, metaplastic breast carcinoma often presents diagnostic and therapeutic challenges for oncologists.
Usage
Usage note: Often abbreviated as MBC in clinical notes, but should be spelled out in formal documentation to avoid confusion with other malignancies.
In Context
- "The pathology report confirmed metaplastic breast carcinoma with squamous differentiation." — Pathology report
- "Given the rarity of metaplastic breast carcinoma, the multidisciplinary team consulted external experts." — Clinical case discussion