multifocal disease
Multiple tumor foci within the same quadrant or region of the breast, typically within 5cm of each other.
Full Definition
Multifocal disease refers to the presence of multiple distinct tumor foci within the same quadrant or anatomical region of the breast, usually defined as separate lesions within 5 centimeters of each other. This differs from multicentric disease, where tumors are located in different quadrants or more than 5cm apart. Multifocal breast cancer may represent separate primary tumors or local spread from a single primary focus. The presence of multifocal disease influences surgical planning, as it may require wider excision margins or consideration of mastectomy rather than breast-conserving surgery.
Usage
Usage note: Distinguish from multicentric disease based on distance and quadrant location.
In Context
- "MRI revealed multifocal disease with three separate enhancing foci within the upper outer quadrant." — Radiology report
- "The presence of multifocal disease prompted discussion of mastectomy versus wide local excision." — Multidisciplinary team meeting